Thermo Fisher Scientific DUT Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

Product Specifications

Product Specific Information

Protein Sequence:

MTPLCPRPAL CYHFLTSLLR SAMQNARGAR QRAEAAVLSG PGPPLGRAAQ HGIPRPLSSA GRLSQGCRGA STVGAAGWKG ELPKAGGSPA PGPETPAISP SKRARPAEVG GMQLRFARLS EHATAPTRGS ARAAGYDLYS AYDYTIPPME KAVVKTDIQI ALPSGCYGRV APRSGLAAKH FIDVGAGVID EDYRGNVGVV LFNFGKEKFE VKKGDRIAQL ICERIFYPEI EEVQALDDTE RGSGGFGSTG KN

Target Information

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate.
This reaction serves two cellular purposes:

1. Providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication.
2. Limiting intracellular pools of dUTP.

Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process results in removal and reincorporation of dUTP, leading to DNA fragmentation and cell death.
Alternative splicing of this gene leads to isoforms that localize to either the mitochondrion or nucleus.
A related pseudogene is located on chromosome 19.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.