Thermo Fisher Scientific DUT Monoclonal Antibody (1C9)
Thermo Fisher Scientific DUT Monoclonal Antibody (1C9)은 인간 DUT 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS(pH 7.4) 용액 형태로 제공되며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific DUT Monoclonal Antibody (1C9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C9 |
| Immunogen | DUT (AAH33645, 68–164 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
TDIQIALPSG CYGRVAPRSG LAAKHFIDVG AGVIDEDYRG NVGVVLFNFG KEKFEVKKGD RIAQLICERI FYPEIEEVQA LDDTERGSGG FGSTGKN
Target Information
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes:
- Providing a precursor (dUMP) for thymine nucleotide synthesis required for DNA replication.
- Limiting intracellular pools of dUTP.
Elevated dUTP levels lead to uracil incorporation into DNA, triggering excision repair by uracil glycosylase, which can result in DNA fragmentation and cell death. Alternative splicing yields isoforms localized to mitochondria or nucleus. A related pseudogene is located on chromosome 19.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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