Thermo Fisher Scientific CACNG1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

-

Immunocytochemistry (ICC/IF)

1:100-1:500

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 30-110 of human CACNG1 (NP_0007181) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CACNG1,uniProtId:Q06432-1,ncbiNodeId:9606,antigenRange:30-110,antigenLength:222,antigenImageFileName:PA5-87564_CACNG1_Q06432-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87564_CACNG1_Q06432-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.58 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804257

Product Specific Information

Immunogen sequence: DHWAVLSPHM EHHNTTCEAA HFGLWRICTK RIPMDDSKTC GPITLPGEKN CSYFRHFNPG ESSEIFEFTT QKEYSISAAA I; Positive Samples: Mouse skeletal muscle, Mouse liver, Mouse kidney, Rat skeletal muscle, Rat liver, Rat kidney; Cellular Location: Membrane, Multi-pass membrane protein

Target Information

Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an alpha1 subunit, a beta subunit, a gamma subunit and an alpha2 delta subunit. The beta subunit is encoded by four genes, designated beta1-beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the alpha1 subunit. L-type Ca ++ CP gamma1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP gamma1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP gamma1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anesthetics and depolarizing muscle relaxants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.