Thermo Fisher Scientific CACNG1 Polyclonal Antibody
Thermo Fisher Scientific의 CACNG1 Polyclonal Antibody는 Mouse와 Rat 시료에 반응하며, WB, ICC/IF, ELISA에 적합합니다. Rabbit IgG 기반의 비결합형 액상 항체로, 고순도 친화성 크로마토그래피로 정제되었습니다. 신경전달 관련 칼슘 채널 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 30–110 of human CACNG1 (NP_0007181) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804257 |
Product Specific Information
- Immunogen sequence: DHWAVLSPHM EHHNTTCEAA HFGLWRICTK RIPMDDSKTC GPITLPGEKN CSYFRHFNPG ESSEIFEFTT QKEYSISAAA I
- Positive Samples: Mouse skeletal muscle, Mouse liver, Mouse kidney, Rat skeletal muscle, Rat liver, Rat kidney
- Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Voltage-dependent calcium channels are essential for neurotransmitter release.
L-type (long-lasting current) voltage-dependent calcium channels are composed of four subunits: alpha1, beta, gamma, and alpha2 delta.
The beta subunit is encoded by four genes (beta1–beta4), contributing to calcium current diversity and alpha1 subunit trafficking.
L-type Ca²⁺ channel gamma1 (CACNG1) is a 222 amino acid multi-pass membrane protein of the PMP-22/EMP/MP20 family.
It is expressed in skeletal muscle and acts as a subunit of the dihydropyridine (DHP)-sensitive calcium channel, playing a role in excitation-contraction coupling.
CACNG1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant skeletal muscle disorder triggered by inhalation anesthetics and depolarizing muscle relaxants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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