Thermo Fisher Scientific TIM3 Recombinant Rabbit Monoclonal Antibody (108)
Human TIM-3/HAVCR2 인식용 재조합 토끼 단클론 항체로, 높은 특이성과 일관성을 제공. ELISA에 적합하며 보존제가 없는 액상 형태. Protein A 정제, PBS 버퍼, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 108 |
| Immunogen | Recombinant Human TIM-3/HAVCR2 protein (Met1–Arg200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786331 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
This antibody has specificity for Human TIM-3/HAVCR2.
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺Th1 and CD8⁺Tc1 cells.
TIM3 consists of:
- An IgV-like domain
- A mucin-like domain in the extracellular region
- A conserved tyrosine phosphorylation motif in the cytoplasmic region
TIM3 is involved in macrophage activation and induction of autoimmune diseases. It down-regulates aggressive Th1-mediated immune responses and facilitates immune tolerance. Pathological significance of TIM3 has been linked to Experimental Autoimmune Encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and it enhances the severity of EAE in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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