Thermo Fisher Scientific TIM3 Recombinant Rabbit Monoclonal Antibody (108)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Human TIM-3/HAVCR2.

Target Information

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺Th1 and CD8⁺Tc1 cells.

TIM3 consists of:

• An IgV-like domain
• A mucin-like domain in the extracellular region
• A conserved tyrosine phosphorylation motif in the cytoplasmic region

TIM3 is involved in macrophage activation and induction of autoimmune diseases. It down-regulates aggressive Th1-mediated immune responses and facilitates immune tolerance. Pathological significance of TIM3 has been linked to Experimental Autoimmune Encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and it enhances the severity of EAE in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.