Thermo Fisher Scientific PARC/H7-AP1 Polyclonal Antibody
PARC/H7-AP1 폴리클로날 항체로 인간 단백질 타깃에 특이적 반응. Western blot과 면역침전(IP)에 최적화됨. 항원 친화 크로마토그래피로 정제된 고순도 제품. p53 관련 단백질 복합체 연구용으로 적합. 연구용으로만 사용 가능.
- 카탈로그번호
- A300098A
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PARC/H7-AP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:20,000–1:30,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 2475 and the C-terminus (residue 2527) of human P53-associated parkin-like cytoplasmic protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor.
PARC, a large, Parkin-like ubiquitin ligase, has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes.
In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promotes cytoplasmic sequestration of p53.
PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC.
Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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