Thermo Fisher Scientific OSMR Recombinant Rabbit Monoclonal Antibody (202)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Mouse OSMR/IL-31RB.

Target Information

Oncostatin M (OSM) is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit.

OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.

Publication Note: This RefSeq record includes a subset of the publications available for this gene. Please see the Entrez Gene record to access additional publications.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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