Thermo Fisher Scientific Aconitase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Aconitase 1 Polyclonal Antibody는 Human, Mouse, Rat에 반응하는 Rabbit IgG 항체로, WB, IHC, ICC/IF에 사용 가능. Recombinant ACO1 단백질(aa 1-273)을 면역원으로 제작되었으며, Protein A로 정제된 액상 형태. 철 항상성 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human ACO1 aa 1–273 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% Glycerol, 0.2% BSA |
| Contains | 0.05% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802845 |
Target Information
Aconitase 1 (ACO1), also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis.
IREs are stem-loop structures found in the 5′ UTR of ferritin mRNA and in the 3′ UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of ferritin mRNA translation and inhibition of degradation of transferrin receptor mRNA.
Thus, IREB1 is essential for iron metabolism regulation and also exhibits aconitase enzyme activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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