Thermo Fisher Scientific CD137 Recombinant Rabbit Monoclonal Antibody (BLR051F)
CD137(4-1BB) 단백질을 인식하는 재조합 토끼 단일클론 항체로, 인간 시료에 반응합니다. Western blot, IHC, ICC/IF, Flow cytometry, IP 등 다양한 응용에 적합합니다. 고순도 액상 형태로 제공되며, 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 - 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 - 1:500 |
| Flow Cytometry (Flow) | 0.25 µL per 1 × 10⁶ cells |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR051F |
| Immunogen | Recombinant protein representing the extracellular domain of human CD137 (residues 24–189) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1000 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling supports the survival and expansion of activated and memory CD8⁺ T cells while regulating myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that affects peripheral monocyte survival. Soluble forms of CD137 may act as a negative regulatory mechanism in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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