Thermo Fisher Scientific CD137 Recombinant Rabbit Monoclonal Antibody (BLR051F)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:100 - 1:500

-

Immunocytochemistry (ICC/IF)

1:100 - 1:500

-

Flow Cytometry (Flow)

0.25 µL per 1 x 10^6 cells

-

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR051F

Immunogen

Recombinant protein representing the extracellular domain of human CD137 (residues 24-189). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:4-1BB (CD137),uniProtId:Q07011-1,ncbiNodeId:9606,antigenRange:24-189,antigenLength:255,antigenImageFileName:A700-051_4-1BB_CD137_Q07011-1_Rabbit.svg,antigenImageFileNamePDP:A700-051_4-1BB_CD137_Q07011-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

purified

Storage buffer

BBS, pH 7.8 to 8.6

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

Target Information

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.