Thermo Fisher Scientific hCG beta Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:25-1:100

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Beta chain of human chorionic gonadotropin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.0147 mg/mL

Purification

IgG fraction

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_779813

Product Specific Information

PA1-26300 detects hCG from human placenta and placental trophoblast samples.

Target Information

hCG beta is the beta chain of hCG (Human chorionic gonadotropin), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. hCG is made up of alpha and beta subunits that are non-covalently associated. The alpha subunit is similar to those found on the pituitary hormones FSH, LH ans TSH. However, the beta subunit is different in FSH, LH and TSH and are involved in conferring biological specificity. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and Beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). Diseases associated with Hcg dysfunction include gestational trophoblastic tumor and hydatidiform mole, recurrent 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.