Thermo Fisher Scientific SMAD1 Monoclonal Antibody (OTI1C5), TrueMAB
SMAD1 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot과 IHC(Paraffin) 분석에 적합합니다. 고순도(1 mg/mL) 액상 형태이며, PBS/BSA/glycerol buffer에 보관됩니다. 세포 성장 및 신호전달 연구용으로 사용됩니다.
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Applications
- Western Blot (WB): 1:4,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C5 |
| Immunogen | Full length human recombinant protein of human SMAD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene belongs to the SMAD family, which are signal transducers and transcriptional modulators mediating multiple signaling pathways. SMAD1 mediates bone morphogenetic protein (BMP) signals involved in cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand stimulation, SMAD1 is phosphorylated and forms a complex with SMAD4, regulating transcriptional activity. It is also a substrate for E3 ubiquitin ligases such as SMURF1 and SMURF2 and undergoes proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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