Thermo Fisher Scientific SMAD1 Monoclonal Antibody (OTI2D2), TrueMAB
SMAD1 단백질을 인식하는 Mouse 모노클로날 항체로 Western blot 및 IHC(P) 실험에 적합. 인간 유래 단백질에 반응하며, Affinity chromatography로 정제됨. PBS/BSA/glycerol buffer에 보관되며 -20°C에서 안정적.
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Applications
- Western Blot (WB): 1:4,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D2 |
| Immunogen | Full length human recombinant protein of human SMAD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene belongs to the SMAD family, which is related to the Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma genes. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
This protein mediates bone morphogenetic protein (BMP) signals, influencing cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, it becomes phosphorylated and forms a complex with SMAD4, regulating transcription.
SMAD1 is targeted by SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2) and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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