Thermo Fisher Scientific CD1d Monoclonal Antibody (51.1), PE, eBioscience
인간 CD1d 단백질을 인식하는 51.1 클론 단일클론 항체로, PE 형광체가 결합된 제품입니다. Flow Cytometry에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. CD1d 관련 면역학 연구 및 NKT 세포 분석에 적합합니다.
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- 12-0016-42
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
- View 6 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 51.1 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1724019 |
Available Formats
Product Specific Information
The monoclonal antibody 51.1 reacts with human CD1d, a member of the CD1 family similar to non-polymorphic MHC Class I-like molecules. CD1d is a conserved transmembrane receptor of the Immunoglobulin Superfamily and can associate with beta-microglobulin or exist independently, suggesting different mechanisms for glycolipid antigen presentation to CD1d-reactive NKT cells.
CD1d expression is found on peripheral B cells, resting monocytes, cortical thymocytes, and intestinal epithelial cells (IEC) with polarized expression. It is also found at low levels in hepatocytes and is highly expressed in HCV-infected livers compared to normal controls.
The 51.1 monoclonal antibody has functional activity, blocking interactions between CD1d-transfected cells and NKT cells.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested on normal human peripheral blood cells
- Recommended use: 5 µL (0.125 µg) per test (final volume 100 µL; cell count 10⁵–10⁸ cells/test)
- Excitation: 488–561 nm
- Emission: 578 nm
- Laser Compatibility: Blue, Green, Yellow-Green
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin-independent expression has been shown on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of MHC-like glycoproteins. The CD1d gene encodes a transmembrane glycoprotein forming heterodimers with beta-2-microglobulin and mediating lipid/glycolipid antigen presentation to T cells.
The human genome contains five CD1 family genes clustered on chromosome 1. These members differ in localization and lipid ligand specificity. CD1d localizes to late endosomes and lysosomes via a tyrosine-based motif in its cytoplasmic tail.
Associated Diseases: Mycobacterium Malmoense, Autoimmune Disease.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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