Thermo Fisher Scientific CD172a (SIRP alpha) Monoclonal Antibody (CC149)

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1:100–1:200
Publications: - References

Product Specifications

Product Specific Information

This antibody recognizes bovine CD172a, also known as MyD-1 antigen and SIRPA.
CD172a is approximately a 55 kDa single-pass type I membrane protein belonging to the family of signal regulatory proteins (SIRP).
CD172a has been identified as the receptor for CD47.

Target Information

SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells, macrophages, mast cells, and hematopoietic stem cells.

SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src, and insulin receptor, and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways.

Binding of SIRP alpha to CD47 results in phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, mediating recruitment and activation of tyrosine phosphatases SHP-1 and SHP-2.

Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including inhibition of macrophage-mediated phagocytosis and bi-directional activation of T cells and dendritic cells.

SIRP alpha regulates cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones, and cell adhesion, playing a general role in various physiological and pathological processes.
Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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