Thermo Fisher Scientific CD18 (LFA-1 beta) Monoclonal Antibody (BAQ30A)

Applications

Flow Cytometry (Flow)

• Tested Dilution: Neat-1:10

Product Specifications

Product Specific Information

Mouse anti-Bovine CD18, clone BAQ30A, recognizes bovine CD18, also known as ITGB2 or integrin beta-2.

Target Information

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes.
It can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, which participate in cell adhesion and signaling.
CD18 forms heterodimers with four types of CD11 molecules to constitute leukocyte (beta2) integrins:

• αLβ2 (CD11a/CD18, LFA-1)
• αMβ2 (CD11b/CD18, Mac-1, CR3)
• αXβ2 (CD11c/CD18)
• αDβ2 (CD11d/CD18)

These integrins are essential for proper leukocyte migration and intercellular contact.
Absence or reduction of CD18 expression can lead to leukocyte adhesion deficiency-1 or psoriasiform skin disease.
CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin, mediating leukotoxin-induced cytolysis.
Defects in the CD18 gene cause leukocyte adhesion deficiency type I (LAD1).
Two transcript variants encoding CD18 protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.