Thermo Fisher Scientific HIC1 Polyclonal Antibody
HIC1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Western blot에 최적화되어 있습니다. 마우스 반응성이 확인되었으며, 정제된 액상 형태로 제공됩니다. 연구용으로 암 관련 전사 억제 단백질 연구에 활용 가능합니다.
- 카탈로그번호
- PA537864
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 2–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence NTHCAELYASGP, from the internal region of HIC1 (aa193–204) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2554472 |
Product Specific Information
This antibody is predicted to react with mouse, rat, dog, and pig based on sequence homology.
Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in Miller-Dieker syndrome (MDS), and its expression is often suppressed in leukemia and various cancers due to hypermethylation and transcriptional silencing.
HIC-1 acts as a putative tumor suppressor protein mediating transcriptional repression. It is ubiquitously expressed in adult tissues and contains five zinc fingers and an N-terminal POZ (BTB) domain.
In other BTB/POZ proteins such as BCL-6 and PLZF, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex to repress gene transcription. However, HIC-1 does not interact with HDAC complex components, suggesting that its transcriptional repression is independent of the POZ/BTB domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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