Thermo Fisher Scientific Beta-Arrestin 2 Polyclonal Antibody
Beta-Arrestin 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 고순도 액상 형태로 제공되며 4°C에서 보관합니다. FFPE 조직에서는 citrate buffer(pH 6.0)로 epitope retrieval을 권장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 355 and 405 of human Arrestin, Beta 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
Beta-arrestin-2 (ARRB2) is an adaptor protein belonging to the arrestin family, containing N- and C-arrestin domains. It regulates heterotrimeric G protein-coupled receptor desensitization and modulates beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR-mediated nuclear translocation of ERK.
ARRB2 binds phosphorylated beta2ARs, reducing their ability to activate G(S) proteins. Alongside AIP4, ARRB2 mediates CXCR4 entry into a degradative pathway and may participate in hormone-specific desensitization of TSH receptors.
It also acts as a Ca²⁺-binding protein in retinal outer segments, binds P-rhodopsin, and contributes to synaptic transmission in photoreceptor cells. ARRB2 is widely expressed in neuronal tissues and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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