Thermo Fisher Scientific Beta-Arrestin 2 Polyclonal Antibody
Beta-Arrestin 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. 인간 및 오랑우탄 반응성 예측. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 355 and 405 of human Arrestin, Beta 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
Beta-arrestin-2 (ARRB2) is an adaptor protein belonging to the arrestin family, containing N- and C-arrestin domains. It plays a regulatory role in heterotrimeric G protein-coupled receptor desensitization and enhances beta2-adrenergic receptor (β2AR) mediated nuclear translocation of ERK.
ARRB2 binds phosphorylated β2ARs, impairing their ability to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule mediating CXCR4 entry into a degradative pathway. It may also participate in hormone-specific desensitization of TSH receptors.
ARRB2 is a Ca²⁺ binding protein in retinal outer segments, interacts with P-rhodopsin, and contributes to synaptic transmission in photoreceptor cells. It is widely expressed, particularly in neuronal tissues and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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