Thermo Fisher Scientific BRD7 Polyclonal Antibody
BRD7 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot과 IHC(Paraffin) 실험에 적합합니다. 인간 BRD7 C-말단 펩타이드(aa 594–643)를 면역원으로 사용하였으며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–2.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human BRD7 (aa 594–643) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2577100 |
Product Specific Information
- Peptide sequence: KELAQQVTPG DIVSTYGVRK AMGISIPSPV MENNFVDLTE DTEEPKKTDV
- Sequence homology:
- Dog: 86%
- Guinea Pig: 93%
- Horse: 79%
- Human: 100%
- Rabbit: 79%
- Rat: 86%
Target Information
BRD7 acts both as coactivator and as corepressor. It activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating GSK3B phosphotransferase activity. It is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, enabling efficient recruitment of TP53 to target promoters and inhibiting cell cycle progression from G1 to S phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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