Thermo Fisher Scientific ELL2 Polyclonal Antibody

Thermo Fisher Scientific ELL2 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:2,000
Publications: -

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ELL2.

Target Information

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 downregulates tyrosine kinase-regulated pathways by dephosphorylating target proteins. In hematopoietic cells, SHP-1 binds phosphorylated erythropoietin receptors (EpoR) to negatively regulate growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase and downregulation of Ros-dependent proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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