Thermo Fisher Scientific ELL2 Polyclonal Antibody
ELL2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, PBS/glycerol 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5100683
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ELL2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:2,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ELL2 (Accession O00472), corresponding to amino acid residues G161–I211 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850187 |
Product Specific Information
Antibody detects endogenous levels of total ELL2.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 downregulates tyrosine kinase-regulated pathways by dephosphorylating target proteins. In hematopoietic cells, SHP-1 binds phosphorylated erythropoietin receptors (EpoR) to negatively regulate growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase and downregulation of Ros-dependent proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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