Thermo Fisher Scientific Valproic Acid Monoclonal Antibody (VP13-607.1.D5)
Valproic acid에 특이적인 mouse monoclonal antibody입니다. Western blot, ELISA, Immunoprecipitation 등 다양한 분석에 사용 가능합니다. Protein A로 정제된 액상 형태이며 PBS buffer에 보존됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Valproic Acid Monoclonal Antibody (VP13-607.1.D5)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- ELISA (ELISA): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chemical |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VP13-607.1.D5 |
| Immunogen | Valproic acid-KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Valproic acid, valproate sodium, and divalproex are anticonvulsant compounds used to control certain types of seizures in epilepsy treatment.
Valproic acid relieves histone deacetylase (HDAC)-dependent transcriptional repression and induces hyperacetylation of histones both in cultured cells and in vivo. It inhibits HDAC activity in vitro, likely through binding to the catalytic center of HDACs.
Moreover, valproic acid promotes differentiation of carcinoma cells, transformed hematopoietic progenitor cells, and leukemic blasts from acute myeloid leukemia patients. Tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting valproic acid’s potential as an effective cancer therapy agent.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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