Thermo Fisher Scientific MEKK4 Polyclonal Antibody
Human MEKK4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 글리세롤로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific MEKK4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MEKK4. Recombinant protein control fragment (Product #RP-89772) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643868 |
Product Specific Information
Immunogen sequence:
KDREQRGQEN TSGFWLNRSN ELIWLELQAW HAGRTINDQD FFLYTARQAI PDIINEILTF KVDYGSFAFV RDRAGFNGTS VEGQCKATPG TKIVGYSTHH EHLQRQRVSF EQVKRIMELL EYIEALYPSL Q
Highest antigen sequence identity to the following orthologs:
- Mouse: 82%
- Rat: 85%
Target Information
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo, affecting its interaction with TBP. It contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. Binding of DR1 repressor complexes to TBP-promoter complexes may alter DNA conformation and inhibit preinitiation complex assembly, regulating RNA polymerase II transcription.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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