Thermo Fisher Scientific Calmodulin Polyclonal Antibody
Rabbit polyclonal antibody targeting human Calmodulin-1. Suitable for ICC/IF and ELISA applications. High specificity and sensitivity with 4 mg/mL concentration. Supplied in PBS buffer with glycerol, stored at -20°C or -80°C. For research use only.
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- PA5144088
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- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Calmodulin-1 protein (2–149AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3094109 |
Target Information
Calmodulin mediates the control of numerous enzymes, ion channels, aquaporins, and other proteins through Ca²⁺ binding. It stimulates various protein kinases and phosphatases and, together with CCP110 and centrin, regulates the centrosome cycle and cytokinesis.
Calmodulin is a small, highly conserved calcium-binding protein found in all eukaryotic cells. With four calcium-binding domains, this 17 kDa protein serves as an intracellular receptor for regulatory calcium signals. Upon calcium binding, calmodulin undergoes conformational changes enhancing its affinity for target proteins.
It plays roles in energy metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular modulation of cAMP and calcium levels. Calmodulin is the prototype of calcium-modulated proteins with high affinity for calcium and functions in growth, signal transduction, and neurotransmitter synthesis and release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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