Thermo Fisher Scientific SCK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

Immunogen sequence:
EHLYVNTQGL DAPEPEDSPK KDLFDMRPFE DALKLHECSV AAGVTAAPLP LEDQWPSPPT RRAPVAPTEE QLRQEPWYHG RMSRRAAERM LRADGD

Antigen sequence identity:

• Mouse: 82%
• Rat: 85%

Target Information

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events.
Shc-like protein (Sck) is a neuronal adaptor protein that contains:

• N-terminal PTB (phosphotyrosine binding) domain
• Collagen homology (CH) domain
• Conserved C-terminal SH2 domain

Human Sck transcripts are highly expressed in liver, pancreas, prostate, and ovary.
In vascular endothelial cells, Sck participates in VEGF-induced signal transduction.
Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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