Thermo Fisher Scientific PDZK1 Polyclonal Antibody
Human PDZK1 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 글리세롤 포함. 세포막 단백질 조절 및 신호 전달 연구에 적합.
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Thermo Fisher Scientific PDZK1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PDZK1. Recombinant protein control fragment (Product #RP-88792). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645367 |
Product Specific Information
Immunogen sequence:
MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ DGDRVLRING VFVDKEEHMQ VVDLVRKSGN SVTLLVLDGD SYEKAV
Sequence identity:
- Mouse: 91%
- Rat: 92%
Target Information
PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cell apical domains. It may coordinate various regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it clusters functionally dependent proteins and modulates their trafficking and activity. PDZK1 may also play a role in multidrug resistance via interaction with ABCC2 and PDZK1IP1 and can potentiate CFTR chloride channel activity. It connects SCARB1 with intracellular cholesterol transport mechanisms and may regulate Na(+)-dependent phosphate cotransport in renal tubular function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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