Thermo Fisher Scientific MRC2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:50-1:200

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MRC2

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644097

Product Specific Information

Immunogen sequence: EEEHFVANML NKIFGESEPE IHEQHWFWIG LNRRDPRGGQ SWRWSDGVGF SYHNFDRSRH DDDDIRGCAV LDLASLQWVA MQCDTQLDWI CKIPRGTDVR EPDDSPQGRR EWLRFQEAEY KFFEHHSTWA QAQRICTWFQ AELTSVHSQ

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 90%.

Target Information

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.