Thermo Fisher Scientific NCAPD2 Recombinant Rabbit Monoclonal Antibody (5E0Q9)
Recombinant rabbit monoclonal antibody recognizing NCAPD2 (clone 5E0Q9). Validated for WB and ELISA in human and mouse samples. Produced in HEK293 cells, purified by Protein A, and supplied as liquid. Suitable for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5E0Q9 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 100–200 of human CNAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
Product Specific Information
Immunogen Sequence:
LDDTTLSGSD RNAHLNALKM NCYALIRLLE SFETMASQTN LVDLDLGGKG KKARTKAAHG FDWEEERQPI LQLLTQLLQL DIRHLWNHSI IEEEFVSLVT G
Target Information
Regulatory subunit of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condensed chromosomes. The condensin complex likely introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. It may target the condensin complex to DNA via its C-terminal domain and promote resolution of double-strand DNA catenanes between sister chromatids. Condensin-mediated compaction increases tension in catenated sister chromatids, facilitating type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, it may ensure accurate mitotic chromosome condensation in neuronal stem cells, influencing neuron pool size and cortex development. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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