Thermo Fisher Scientific MKP3 Polyclonal Antibody
MKP3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot 및 면역세포화학(ICC/IF)에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 인간에 반응하며, 원숭이·개·소·말에서도 예측 반응합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptides corresponding to human MKP3 (aa71–89, aa178–195) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 30% glycerol, 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723365 |
Product Specific Information
This antibody is predicted to react with Monkey, Dog, Bovine, and Horse.
Target Information
DUSP6 (Dual Specificity Phosphatase 6) is a member of the dual specificity protein phosphatase subfamily. These enzymes inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. DUSP6 negatively regulates MAP kinase family members such as MAPK/ERK, SAPK/JNK, and p38, which are involved in cellular proliferation and differentiation.
Distinct members of this phosphatase family show different substrate specificities, tissue distributions, subcellular localizations, and inducibility by extracellular stimuli. DUSP6 inactivates ERK2, is highly expressed in heart and pancreas, and is localized in the cytoplasm. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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