Thermo Fisher Scientific IDH1 Monoclonal Antibody (OTI2H9), TrueMAB
IDH1 (mutant R132H) 단백질을 특이적으로 인식하는 Mouse IgG1 단일클론 항체. Western blot과 Immunocytochemistry에 최적화되어 있으며, 액상 형태로 1 mg/mL 농도 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성을 보장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H9 |
| Immunogen | Full-length protein expressed in 293T cell transfected with human IDH1 expression vector (Target: IDH1 mutant R132H, UniProt ID: O75874-1, Range: 1–414, Length: 414) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent enzymes localized to the mitochondrial matrix, and two NADP(+)-dependent enzymes, one mitochondrial and the other cytosolic.
The NADP(+)-dependent cytosolic enzyme encoded by IDH1 contains a PTS-1 peroxisomal targeting signal sequence and plays key roles in NADPH regeneration within peroxisomes and cytoplasm.
This antibody is specific for IDH1 (mutant R132H).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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