Thermo Fisher Scientific DGUOK Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:

RLSIEGNIAV GKSTFVKLLT KTYPEWHVAT EPVATWQNIQ AAGTQKACTA QSLGNLLDMM YREPARWSYT FQTFSFLSRL KVQLEPFPEK LLQARKPVQI FERSVYSDRY IFAKNLFENG SLSDIEWHIY QDWHSFLLWE FASRITLHGF IYLQASPQVC LKRLYQRARE EEKGIELAYL EQLHGQHEAW LIHKTTKLHF EALMNIPVLV LDVNDDFSEE VTKQEDLMRE VNTFVKNL

Target Information

Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxyribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates.

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK, also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver, and lymphoid tissues.

Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS), a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs (typically muscle or liver) or multiple tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.