Thermo Fisher Scientific FBXO32 Polyclonal Antibody

Thermo Fisher Scientific FBXO32 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 0.3–1 µg/mL
• Peptide ELISA: Antibody detection limit dilution 1:16,000

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Product Specifications

Product Specific Information

• Predicted to react with bovine, porcine, and rat based on sequence homology.
• Tested in Peptide ELISA with antibody detection limit dilution of 1:16,000.

Target Information

FBXO32 encodes a member of the F-box protein family, characterized by an approximately 40 amino acid motif called the F-box.
These proteins are part of the SCF ubiquitin ligase complex, functioning in phosphorylation-dependent ubiquitination.
F-box proteins are categorized into three classes:

• Fbws: containing WD-40 domains
• Fbls: containing leucine-rich repeats
• Fbxs: containing various protein-protein interaction modules or lacking recognizable motifs

FBXO32 belongs to the Fbxs class and contains an F-box domain. It is highly expressed during muscle atrophy; mice deficient in FBXO32 are resistant to atrophy.
Thus, FBXO32 is a potential drug target for muscle atrophy treatment.
Alternative splicing results in two transcript variants encoding isoforms of different sizes.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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