Thermo Fisher Scientific MeCP2 isoform 1 Polyclonal Antibody, Biotin
MeCP2 isoform 1 단백질을 인식하는 Biotin-conjugated rabbit polyclonal antibody. Western blot, ELISA, IP에 적합하며 인간 및 마우스 시료에 반응. 고순도 친화 크로마토그래피 정제, 안정한 액상 포맷으로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 on mouse Methyl-CpG-binding Protein 2 isoform 1 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that contain a methyl-CpG binding domain. MECP2 binds specifically to methylated DNA, which is a key modification in eukaryotic genomes essential for mammalian development. It can repress transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. While dispensable in stem cells, it is essential for embryonic development. Mutations in the MECP2 gene are the primary cause of Rett syndrome, a progressive neurological developmental disorder and a major cause of mental retardation in females.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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