Thermo Fisher Scientific MeCP2 isoform 1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing MeCP2 isoform 1. Validated for WB, ELISA, and IP in human, mouse, and rat samples. Affinity-purified, liquid form, unconjugated. Ideal for research on methyl-CpG-binding proteins and Rett syndrome mechanisms.
- 카탈로그번호
- MECP2E1-121AP
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 of mouse methyl-CpG-binding protein 2 isoform 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MECP2 is a nuclear protein belonging to the methyl-CpG-binding domain (MBD) family, which includes MBD1, MBD2, MBD3, and MBD4. It specifically binds to methylated DNA, a key modification in eukaryotic genomes that regulates gene expression and development. MECP2 represses transcription from methylated promoters and is X-linked, subject to X inactivation. It is essential for embryonic development, and mutations in the MECP2 gene cause most cases of Rett syndrome, a progressive neurological disorder and a major cause of mental retardation in females.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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