Thermo Fisher Scientific CD44 Polyclonal Antibody
인간 CD44 단백질을 인식하는 산양 유래 폴리클로날 항체로, WB 및 IHC(P) 실험에 적합합니다. 비접합 액상 형태이며 0.5 mg/mL 농도로 제공됩니다. 다양한 CD44 아이소폼을 인식하며 세포 부착 및 이동 연구에 활용 가능합니다.
- 카탈로그번호
- PA5143101
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–0.03 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-NRDGTRYVQKGEYRT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933740 |
Product Specific Information
- This antibody is expected to recognize reported isoforms 1, 2, 3, 4, 6, 7, 8 (NP_000601.3; NP_001001389.1; NP_001001390.1; NP_001001391.1; NP_001189484.1; NP_001189485.1; NP_001189486.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, brain white matter, and epithelial cells of the intestine and breast. Multiple isoforms exist, with CD44H being predominant in normal tissues.
It serves as a receptor for hyaluronic acid (HA), mediating cell-cell interactions, adhesion, and migration. CD44 plays key roles in lymphocyte activation, recirculation, and homing. Expression levels may increase in certain carcinomas and correlate with metastatic potential.
CD44 is expressed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes. Bone marrow myeloid cells and memory T cells exhibit high expression, while peripheral B and T cells can upregulate CD44 upon stimulation.
Alternative splicing generates multiple isoforms with distinct functions. CD44 dysfunction is associated with diseases such as superficial keratitis and lichen sclerosus, and may be related to tumor metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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