Thermo Fisher Scientific HPK1 Polyclonal Antibody
HPK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 Immunoprecipitation에 사용 가능. Human 시료 반응성. 항원 친화 크로마토그래피 정제 및 Protein A 처리. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human MAP4K1 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902652 |
Target Information
MAP4K1 (also known as HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily. It functions as an upstream activator of the MEKK/JNK/SAPK signaling pathway and modulates T cell receptor (TCR) signaling and proliferation by phosphorylating the adaptor protein SLP-76.
JNKs/SAPKs play a key role in mammalian stress responses. MAP4K1 is predominantly expressed in hematopoietic progenitor cells and is distantly related to p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20. HPK1 specifically activates JNK1 and enhances AP-1-mediated transcriptional activity. It binds and phosphorylates MEKK1 directly, and JNK1 activation by HPK1 is inhibited by dominant-negative MEKK1 or MKK4/SEK mutants. Unlike PAK65, HPK1 lacks the small GTPase Rac1/Cdc42-binding domain and does not bind Rac1 or Cdc42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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