Thermo Fisher Scientific APE1 Polyclonal Antibody
APE1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 검증 완료. 인간 및 마우스 반응성, 다양한 종에서 예측 반응성 있음. 항원 친화 크로마토그래피로 정제된 액상 항체로 DNA 손상 복구 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human APE1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792371 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (97%), Rat (96%), Dog (98%), Pig (97%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (97%).
- Positive control: A431, mouse brain, HeLa.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional enzyme involved in DNA repair and redox regulation of proteins related to oxidative signaling, transcription factor control (Fos, Jun, NF-kB, Myb, HIF-1α, CREB, Pax), cell cycle regulation (p53), and apoptosis.
APE repairs abasic sites in DNA caused by spontaneous loss or oxidative damage, chemical hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases.
Expression of APE varies across tissues and developmental stages. It is regulated by phosphorylation through casein kinase II and is upregulated in hypoxia-reoxygenation and certain malignancies, while downregulation is associated with apoptosis induction.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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