Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI1C8)
N4BP2L2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 IHC(P) 검증 완료. 인간 시료에 반응하며, 마우스 IgG2a 아이소타입. PBS 기반 용액 형태로 제공되며, -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C8 |
| Immunogen | Full length human recombinant protein of N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723387 |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is significantly down-regulated after exposure to arsenic compounds, preceding neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the ELA2 gene (encoding Neutrophil Elastase) cause cyclic haematopoiesis, leading to reduced neutrophil counts and increased susceptibility to opportunistic infections.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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