Thermo Fisher Scientific SLC1A1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous PubMed (Misc)

• Publications: View 2 publications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide shares 96% identity with rat and mouse sequence.
• Specificity: EAAT3.

Target Information

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitotoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: GLAST-1, GLT-1, EAAC-1, and EAAT-4.
EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features include eight membrane-spanning alpha-helices and a loop-pore structure unique among secondary transporters.
Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity, although no neurodegeneration was observed over a period of 12 months.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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