Thermo Fisher Scientific PRRX2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000
• Publications: [참고 문헌 없음]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: [참고 문헌 없음]

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total PRRX2.

Target Information

The paired-class homeobox genes PRX1 and PRX2 are necessary for craniofacial and limb development and are expressed in similar patterns in the cranial mesenchyme, limb buds, axial mesoderm, and branchial arches.
These proteins exhibit different expression patterns in heart and brain tissue. PRX1 is expressed in endocardial cushions, semilunar and atrioventricular valves, whereas PRX2 is initially expressed diffusely in myocardium and later in the ventricular septum.
PRX2 is not expressed in the brain, while PRX1 is found in the ventral hypothalamus and telencephalon.
Murine mutants lacking PRX1 function show skeletal defects, while PRX2 mutants alone do not. PRX1/PRX2 double mutants present unique abnormalities not seen in PRX1-deficient mice.
Neither PRX1 nor PRX2 transcripts are detected in normal adult rat pulmonary arteries, but vascular disease induces PRX gene expression co-localized with Tenascin-C expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.