Thermo Fisher Scientific WDR24 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human WDR24. Recombinant protein control fragment (Product #RP-97604). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WDR24,uniProtId:Q96S15-1,ncbiNodeId:9606,antigenRange:57-158,antigenLength:790,antigenImageFileName:PA5-58820_WDR24_Q96S15-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58820_WDR24_Q96S15-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649558

Product Specific Information

Immunogen sequence: EQFVEKLNLR VGRKPSLNLS CADVVWHQMD ENLLATAATN GVVVTWNLGR PSRNKQDQLF TEHKRTVNKV CFHPTEAHVL LSGSQDGFMK CFDLRRKDSV ST

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

WDR24, as a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. WDR24 is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.