Thermo Fisher Scientific KDM4C Monoclonal Antibody (OTI8A1), TrueMAB
KDM4C 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P) 검증 완료. Human 시료에 반응하며, 0.6 mg/mL 농도의 액상 형태로 제공. PBS, BSA, glycerol 기반 buffer에 보관하며 -20°C에서 안정적. 연구용 시약으로 히스톤 탈메틸화 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8A1 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human KDM4C expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Jumonji domain-containing protein 2C (JMJD2C), also known as Lysine-specific demethylase 4C (KDM4C), is a histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, thereby playing a central role in the histone code.
KDM4C does not demethylate histone H3 Lys-4, H3 Lys-27, or H4 Lys-20. It acts on trimethylated H3 Lys-9 and H3 Lys-36 residues, but shows no activity on mono- or dimethylated forms.
The demethylation of lysine residues generates formaldehyde and succinate.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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