Thermo Fisher Scientific PON1 Monoclonal Antibody (OTI1F7)
인간 PON1 단백질을 특이적으로 인식하는 Mouse IgG2b 단클론 항체로, WB, IHC, Flow, ELISA 등 다양한 연구용 분석에 적합. 고순도 친화 크로마토그래피 정제 제품으로 안정적인 액상 형태 제공. -20°C 보관, 반복 동결·해동 주의.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F7 |
| Immunogen | Full length human recombinant protein of PON1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725070 |
Target Information
The paraoxonase (PON) gene family in humans includes three members: PON1, PON2, and PON3, located on chromosome 7q21.3–22.1.
PON1 is synthesized mainly in the liver and secreted into plasma, where it associates with high-density lipoproteins (HDL).
It hydrolyzes active metabolites of organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon) and nerve agents such as sarin, soman, and VX.
PON1 polymorphism is linked to neurodegeneration and may be an independent risk factor for Parkinson’s disease.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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