Thermo Fisher Scientific CaMKII gamma Polyclonal Antibody, FITC

Applications and Tested Dilutions

Product Specifications

Target Information

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin binding and autophosphorylation. It is involved in dendritic spine and synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, it plays a structural role in actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments independently of its kinase activity. This structural function is required for proper targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity, enabling long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, it promotes dendritic arborization, while in mature neurons, it supports dendritic remodeling. It also modulates skeletal muscle function in response to exercise by regulating sarcoplasmic reticulum Ca(2+) transport in slow-twitch muscles and controlling Ca(2+) release in fast-twitch muscles through phosphorylation of triadin and phospholamban (PLN/PLB).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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