Thermo Fisher Scientific EIF3S3 Monoclonal Antibody (3B12)
EIF3S3 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse monoclonal antibody (Clone 3B12). Western blot과 ELISA에 적합하며, 고순도 affinity chromatography로 정제된 액상형 비결합 항체. 인간 시료 반응성, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B12 |
| Immunogen | EIF3S3 (NP_003747, 152–250 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
YDPIKTAQGS LSLKAYRLTP KLMEVCKEKD FSPEALKKAN ITFEYMFEEV PIVIKNSHLI NVLMWELEKK SAVADKHELL SLASSNHLGK NLQLLMDRV
Target Information
eIF3H is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, required for several steps in the initiation of protein synthesis.
The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S pre-initiation complex (43S PIC).
It stimulates mRNA recruitment and scanning for AUG recognition, and is also involved in disassembly and recycling of post-termination ribosomal complexes.
The eIF-3 complex specifically initiates translation of mRNAs involved in cell proliferation, differentiation, and apoptosis, using diverse RNA stem-loop binding modes for activation or repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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