Thermo Fisher Scientific CD20 Monoclonal Antibody (LT20), FITC

Applications

• Flow Cytometry (Flow): 20 µL / 1×10⁶ cells

Product Specifications

Available Formats

• Unconjugated (MA1-19380)
• APC (MA1-19472)
• Biotin (MA1-19525)
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD20 (Bp35), a 33–37 kDa non-glycosylated membrane receptor with four transmembrane domains. It is expressed on B lymphocytes (lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.

Target Information

CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells. It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. CD20 is associated with lipid rafts, and its expression correlates with surface IgM expression. It remains on the cell surface following monoclonal antibody treatment, making it a valuable target for therapeutic B-cell depletion. CD20 dysfunction is linked to Ms4a1-related common variable immune deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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