Thermo Fisher Scientific TPO (Thyroid Peroxidase) Monoclonal Antibody (TPO, 3701)
인간 TPO 단백질을 인식하는 마우스 단클론 항체. IHC(P)와 Peptide Array에 사용 가능. Protein A/G로 정제된 액상 형태로 제공되며, 4°C에서 보관. 갑상선 관련 단백질 연구용으로 적합.
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- 7173-MSM11-P1
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TPO, 3701 |
| Immunogen | Recombinant fragment of human TPO (around aa 685–804) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For IHC (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Thyroid Peroxidase (TPO) encodes a membrane-bound glycoprotein enzyme essential for thyroid gland function. It catalyzes iodination of tyrosine residues in thyroglobulin and formation of phenoxy-ester bonds between iodinated tyrosines, producing thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Mutations in TPO are associated with disorders such as congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants exist, though some full-length forms remain undetermined.
Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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