Thermo Fisher Scientific TPO (Thyroid Peroxidase) Monoclonal Antibody (TPO, 3700)
인체 TPO 단백질을 인식하는 마우스 단클론 항체로, 면역조직화학(IHC) 및 펩타이드 배열 분석에 적합합니다. Protein A/G로 정제된 액상 항체이며, PBS 버퍼에 BSA와 sodium azide가 포함되어 있습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 7173-MSM10-P1
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Thermo Fisher Scientific TPO (Thyroid Peroxidase) Monoclonal Antibody (TPO, 3700)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TPO, 3700 |
| Immunogen | Recombinant fragment of human TPO (around aa 685–804) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Thyroid Peroxidase (TPO) encodes a membrane-bound glycoprotein that functions as an enzyme essential for thyroid gland activity. It catalyzes iodination of tyrosine residues in thyroglobulin and formation of phenoxy-ester bonds between iodinated tyrosines, leading to thyroid hormone synthesis (thyroxine and triiodothyronine).
Mutations in TPO are associated with thyroid-related disorders such as congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified, though some full-length variants remain undetermined.
Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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