Thermo Fisher Scientific Sortilin Polyclonal Antibody
Sortilin 단백질을 인식하는 Sheep 유래 Polyclonal Antibody로, WB 및 IHC에 사용 가능. Rat 및 Mouse 반응성. Lyophilized 형태로 제공되며, 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용.
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Thermo Fisher Scientific Sortilin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the extracellular, N-terminal region of rat Sortilin (Neurotensin receptor 3, NTR3, Sort1) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen shares 95% identity with mouse sequence.
- Specificity: Sortilin.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
It is required for protein transport from the Golgi apparatus to the lysosomes by a pathway independent of the mannose-6-phosphate receptor (M6PR).
Also involved in protein transport from the Golgi apparatus to endosomes.
Sortilin promotes neuronal apoptosis by mediating endocytosis of proapoptotic precursors of BDNF (proBDNF) and NGFB (proNGFB).
Additionally, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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