Thermo Fisher Scientific PECAM1 Monoclonal Antibody (UMAB32), UltraMAB
PECAM1(CD31) 단백질을 인식하는 UMAB32 클론의 마우스 단클론 항체로, Western blot, IHC, Flow cytometry 등 다양한 응용에 적합. 인간 반응성, 고순도 친화 크로마토그래피 정제, 동결건조 형태로 안정적 보관 가능.
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- UM500032CF
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ChIP assay (ChIP) | Assay-dependent | |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB32 |
| Immunogen | Full-length human recombinant protein of human PECAM1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve ~1 mg/mL concentration.
- For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD31 (PECAM-1, platelet endothelial cell adhesion molecule-1) is an inhibitory coreceptor regulating T and B cell signaling via ITIM motifs. It is expressed throughout the vascular compartment, primarily at cell junctions. The N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions. CD31 functions in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immunoregulation, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis. It is a key regulatory molecule in the vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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