Thermo Fisher Scientific DISC1 Polyclonal Antibody
Rabbit polyclonal antibody against human DISC1 protein. Validated for Western blot (1:500–1:3,000). Suitable for neuronal and schizophrenia-related research. Supplied as a liquid, 1 mg/mL in PBS with 10% glycerol. Store at 4°C short term or -20°C long ...
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DISC1 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Positive Control: Molt-4
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human DISC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792366 |
Product Specific Information
- Keep as concentrated solution.
- Centrifuge briefly prior to opening the vial.
- Store product as a concentrated solution.
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein involved in neuronal functions dependent on proper cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.
It is expressed in the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus.
Loss of DISC1 function is associated with structural differences in the brain and linked to schizophrenia due to chromosomal translocations.
DISC1 interacts with various proteins such as MIPT3, MAP1A, NUDEL, alpha-actinin 2, beta 4-spectrin, ATF-4, and ATF-5, playing roles in intracellular transport and neuronal development.
Decreased DISC1 expression accelerates neuronal integration and affects dendritic development and synapse formation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.