Thermo Fisher Scientific TRPV1 Polyclonal Antibody
TRPV1 단백질을 인식하는 양에서 유래한 polyclonal antibody로, WB 및 IHC에 사용 가능. 합성 rat TRPV1 펩타이드로 면역화됨. 비결합형, 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용.
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Thermo Fisher Scientific TRPV1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat TRPV1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1091061 |
Product Specific Information
Reconstitute with 100 µL of distilled water before use.
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel related to TRP family members such as TRPC3 and TRPC6, permeable to calcium, magnesium, sodium, and potassium.
It contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains.
TRPV1 is activated by noxious heat and may function as a transducer of painful thermal stimuli in vivo. It mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons.
Expression is mainly in sensory ganglia neurons. Four transcript variants with different 5′ UTR sequences have been described.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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